Life Sciences & Biotechnology
Title : | Genomic diversity and function analysis of chemosensory systems and chemoreceptor proteins, along with identification of sensory ligand molecules in family Vibrionaceae organisms |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Genetics |
Principal Investigator : | Dr. Gaurav sharma, Indian Institute of Technology (IIT) Hyderabad, Telangana |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | sharmaG@bt.iith.ac.in |
Details
Executive Summary : | The Vibrionaceae family comprises 14 genera and 150 species, with a dozen species causing human or animal infections through raw infected seafood or water. Vibrio cholerae is one of the top 20 bacterial pathogens with the highest global mortality. The family has three chemosensory systems (Csss) that sense external signal molecules via methyl-accepting chemotaxis protein (MCP) proteins. Only a few of the 44 MCPs are known to sense dedicated compounds, and others need to be characterized. This computational study aims to characterize the function of unknown Css and MCPs involved in the survival and pathogenicity of Vibrio spp. by studying complete genomes of 695 family Vibrionaceae organisms. The study aims to identify one additional Css type and many diverse MCPs in Vibrio organisms, and analyze a larger dataset to reveal the vast diversity of Css and MCPs in these organisms. Comparative genomics, virtual screening, and protein-protein interaction studies will help identify common and unique molecules these organisms sense in their respective environments. |
Total Budget (INR): | 28,02,310 |
Organizations involved