Life Sciences & Biotechnology
Title : | Enhancing rice arsenic resistance by focusing on specific microRNA that targets gama-glutamyl cysteine synthetase |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Genetics |
Principal Investigator : | Dr. Poonam Tiwari, University of Lucknow, Uttar Pradesh |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | tpoonam.rs@gmail.com |
Details
Executive Summary : | Arsenic toxicity poses a significant threat to human health, especially in south East Asian countries. The high levels of arsenic in food and drinking water, particularly in rice, expose the population to life-threatening diseases. To address this, research is focused on studying arsenic absorption, accumulation, transport, and detoxification in rice. Glutamyl cysteine synthetase (ECs) is a potential target for modulating GsH biosynthesis. Micro RNA (miRNAs) play a crucial role in response to metal stress, and understanding their functions is crucial for developing arsenic-resistant rice varieties. The proposed project aims to target miRNAs that regulate the synthesis of the OsECs enzyme in rice, aiming to reduce arsenic uptake in grains and leaves. ECs is a pivotal enzyme in GsH biosynthesis, offering potential for manipulating the cellular GsH pool. |
Total Budget (INR): | |
Organizations involved