Research

Life Sciences & Biotechnology

Title :

Adapting the standard SIR model for COVID-19 and effects of climate and lockdowns on infectious spread of SARS-CoV-2

Area of research :

COVID-19 Research, Life Sciences & Biotechnology

Focus area :

COVID-19 Management

Principal Investigator :

Dr M Michael Gromiha, Professor, Indian Institute of Technology (IIT) Madras

Timeline Start Year :

2020

Contact info :

Details

Executive Summary :

In this work, a mathematical model is developed to estimate the impact of SARS-CoV-2. Based on climatic conditions, the countries will be clustered and the difference in model parameters will be studied. The study aims to gauge the effectiveness of lockdown measures using the model.

Outcome/Output:

The fitted hybrid SEIQR model for Indian population highlights the influence of lockdown-imposed restrictions and regulations on COVID-19 disease transmission. The model also indicates that the number of unidentified COVID-19 recovered individuals is greater than the identified individuals. Disordered-to-order transition of residues in spike protein upon ACE2 binding is shown to be important for tackling COVID-19 The interaction energy and interface area of SARS-Cov-2 is higher than the mild strain, NL63.

Organizations involved

Implementing Agency :

Indian Institute of Technology (IIT) Madras

Funding Agency :

Department of Science and Technology (DST), Govt of India

Related Research

i-Technology Business Incubator-BLDE Deemed to be University to be established at Vijayapura.
Understanding the role of PARP16 in the development of cardiac lipotoxicity
Understanding the regulation of gap junction protein Connexin 43 in Murine-beta-Coronavirus, MHV induced acute and chronic phase inflammation by combining TNF-alpha, IL-10 and TGF- beta signalling triad.
Investigations into the tetanus toxoid mediated regulation of neural stem cells derived hippocampal regenerative plasticity through extracellular vesicles in experimental models: A biomedical implication for a non-invasive paradigm to alleviate cognitive impairments
A comprehensive assessment of nickel uptake in Cherry tomato (Lycopersicon esculentum Mill.), through study of cell death, gene interaction, epigenetic changes and analysis of ameliorating capacities of a designed "Cerium-silica nanocomposite” using stress training principles.