Research

Chemical Sciences

Title :

Assembly of novel polyheterocyclic frameworks using cycloaddition strategy

Area of research :

Chemical Sciences

Focus area :

Organic Chemistry

Principal Investigator :

Prof. M. Bakthadoss, Pondicherry University

Timeline Start Year :

2020

Timeline End Year :

2023

Contact info :

Details

Executive Summary :

This proposal outlines the development of novel synthetic methodologies for the construction of wide variety of polyheterocyclic scaffolds with biological relevance. Furthermore, these strategies will be very useful for the elegant synthesis of various interesting molecular architectures such as tetrahydrospirochromenopyrroloquinoline indolinone derivatives, tricyclic / tetracyclic benzofuropyrrolizines, benzofuropyrroles, benzofuroindolizines and benzofuropyrrolothiazole scaffolds, benzofuro / indolino fused tricyclic frameworks, chromeno pyrazolopyrazolo pyranopyridinone, chromeno[4,3-b]pyrroles, benzofuro[3,2-b]pyrroles, thiopyranochromenyl / thiopyranoquinolinyl phosphonate motifs, thiazolo benzofuropyrimidine / benzochromenopyrimidine derivatives, chromenopyranopyrroloisoquinolines / quinolinopyranopyrroloisoquinolines, fused pyranobenzofuran / thiopyranobenzofuran / benzofurothiazine scaffolds, chromeno[4,3-b]pyridine / tetrahydrobenzofuro[3,2-b]pyridine, benzo[b,d]furan and benzo[c]chromene scaffolds etc. It is important to mention that there is no report available in the literature for accessing these types of compounds. Furthermore, all the proposed compounds will be confirmed with stereochemistry and will be studied for their biological activities. We believe that all the proposed compounds will have various biological activities since it contains various pharmacophore units in their scaffolds.

Co-PI:

Prof. Suman Chakraborty Indian Institute Of Technology Kharagpur, West Bengal,Kharagpur,West Bengal,Paschim Medinipur-721302

Total Budget (INR):

47,25,979

Publications :

 
6

Organizations involved