Life Sciences & Biotechnology
Title : | Bioactive screening and therapeutic evaluation of herbal extracts as potential sources of antivenom |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Prof. H T Lalremsanga, Mizoram University, Mizoram |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | htlrsa@yahoo.co.in |
Equipments : | Soxhlet Apparatus |
Details
Executive Summary : | Snakebite has been considered a neglected health problem especially in the rural areas of the tropics, and the treatment of snakebite is a medical challenge even in advanced healthcare services due to the accompanying tissue damage and other physical complications. Despite anti-venom therapy has been regarded to reduce mortality, the ineffectiveness of immunotherapy against snake venom-induced other physical complications have urged the field of phytochemistry to seek for more effective approaches to counter the main effects induced by snake venoms through the implementation of plant extracts' neutralization properties. This research proposal aimed for screening bioactive compounds which are having inhibitory properties of snake venom activities such as alkaloids, polyphenols, saponins, iridoids, sterols, terpenoids, triterpenes, glycosides, flavonoids etc. For this work, two medicinal plants of Mizoram which have been long known traditionally as a potential remedy for snake will be screened i.e different parts of Alocasia sp. and Calocasia sp. like leave, corms and infloroscence; then, the compound of interest will be isolated and through in-vivo, ex-vivo and in-vitro approaches for screening their neutralization activity against the venom of the three prevalent pit-viper (Crotalidae) species of Mizoram namely Trimeresurus erythrurus, Popeia popeiorum, and Ovophis monticola that have been known to cause several cases of their envenomation in Mizoram. |
Co-PI: | Dr. TC Lalhriatpuii, Regional Institute Of Paramedical And Nursing Sciences, Aizawl, Mizoram-796017 |
Total Budget (INR): | 34,97,950 |
Organizations involved