Research
Title : | Determining the role of pancreatic alpha-cell autophagy in intra-cellular glucagon turnover and its modulation as an anti-diabetic therapy |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Diabetic therapy |
Principal Investigator : | Dr. Rohit A. Sinha, Assistant Professor, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPIMS), Lucknow |
Timeline Start Year : | 2017 |
Timeline End Year : | 2022 |
Contact info : | anthony.rohit@gmail.com |
Details
Executive Summary : | The incidence of diabetes mellitus (DM) and its associated complications has increased at an alarming rate in India. Recent discoveries have shown that besides insulin, glucagon, also is an important contributor to the disease of diabetes. In diabetes, glucagon secretion is significantly upregulated and limiting its level in diabetics is believed to alleviate hyperglycaemia. In this study we attempt to understand and modulate a cellular degradative process known as autophagy to reduce the amount of glucagon content inside the pancreatic alpha- cells which secrete them. We believe that the results obtained from this study would benefit future diabetes research and treatment. |
Co-PI: | N.A |
Total Budget (INR): | 3,39,34,890 |
Achievements : | N.A |
Publications : | 60 |
Patents : | N.A |
PhD Produced : | N.A |
Innovation (Innovations/ Patents/ Tech Transfer) : | New therapeutic development for endocrine/metabolic diseases. |
Outcome/Output: | New knowledge generation and translational implication to go for Phase-I clinical trials |
Organizations involved
Implementing Agency : | Sanjay Gandhi Post Gradute Institute of Medical Science (SGPGIMS), Lucknow, Uttar Pradesh 226014 Funding Agency :The Wellcome Trust/DBT India Alliance, Hyderabad 500034 | |