Research
Title : | Development of host-directed anti-coronavirus agents |
Area of research : | COVID-19 Research, Life Sciences & Biotechnology |
Focus area : | COVID-19 Therapeutics |
Principal Investigator : | Dr Naveen Kumar, Scientist, National Research Centre on Equines (NRCE), Haryana |
Timeline Start Year : | 2020 |
Timeline End Year : | 2020 |
Contact info : | naveenkumar.icar@gmail.com |
Details
Executive Summary : | This study aims to screen the entire library of small molecule chemical inhibitors for their antiviral action against coronavirus-infectious bronchitis virus (IBV, a poultry virus). |
Publications : | 3 |
Outcome/Output: | Emetine was found to be a low nanomolar (nM) inhibitor against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) besides exhibited protective efficacy against lethal challenge with infectious bronchitis virus (IBV; a chicken coronavirus). Emetine treatment led to a decrease in viral RNA and protein synthesis. In a chromatin immunoprecipitation (CHIP) assay, emetine was shown to disrupt the binding of SARS-CoV-2 mRNA with eIF4E, a cellular cap-binding protein required for initiation of protein translation. |
Organizations involved
Implementing Agency : | National Research Centre on Equines (NRCE), Haryana Funding Agency :Department of Science and Technology (DST), Govt of India | |