Executive Summary : | Organic electrochemistry involves the use of electron transfer between electrodes and an electrolyte for the synthesis of organic molecules. It shares similarities with organic photochemistry, as both involve one or more electron transfer steps. Electrosynthesis has advantages such as achieving carbon-carbon bond formations and functional group transformations under mild conditions, and generating reactive species like radical cations and radical anions. Synthetic chemists are motivated to exploit electrosynthesis to develop efficient strategies for potential organic small molecules. Continuous-flow microfluidic devices have emerged as an attractive synthetic tool due to their high surface-to-volume ratio, excellent mass and heat transfer, and potential for increasing reaction selectivity and reducing reaction time. Electrochemical microreactors offer high efficiency, convenience, and automation for proposed reaction methods. This proposal aims to merge multicomponent reactions (MCR) with electrosynthesis to develop a novel concept for diversity-oriented synthesis (DOS). The project will demonstrate natural product syntheses involving isocyanide as a building block and explore the biological properties of potential molecules in collaboration with the Biotech department of MLSU, ICMR-National Malaria Research Institute, and NIPER, Ahmedabad. |