Computer Sciences and Information Technology
Title : | Investigation of possible selective estrogen receptor modulators |
Area of research : | Life Sciences & Biotechnology, Computer Sciences and Information Technology |
Focus area : | Bioinformatics |
Principal Investigator : | Dr. Om Silakari, Associate Professor, Punjabi University (PU), Patiala |
Timeline Start Year : | 2012 |
Timeline End Year : | 2015 |
Contact info : | omsilakari@rediffmail.com |
Details
Executive Summary : | Computational analyses were successfully employed for the designing of seven multi-targeted agents against ITK, IRAK-4 and COX-2. The designed molecules were chemically synthesized, and extended to the in vitro biological testing against considered three protein targets. Finally, three molecules displayed good inhibitory activity against ITK, IRAk-4 and COX-2, which can be extended for further analyses in the future |
Publications : | 4 |
Organizations involved