Research
Title : | Non-alcoholic fatty liver disease (NAFLD): Novel pathogenic mechanism and therapeutic development |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Non-alcoholic fatty liver disease |
Principal Investigator : | Dr Partha Chakrabarti, Scientist, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata |
Timeline Start Year : | 2020 |
Timeline End Year : | 2025 |
Contact info : | director@iicb.res.in |
Details
Executive Summary : | Objective: Role of Ubiquitin-proteasome system (UPS) in the pathogenesis of NAFLD; Role of non-coding RNA in NAFLD; ER stress - Mitochondrial dysfunction - Autophagy triad during progression of NAFLD and to NASH; Targeted small molecule inhibitors for treatment of NAFLD by preventing ATGL degradation; Development of Novel mTOR inhibitors for reduction of lipogenesis and lipid accumulation in Hepatocytes; Identification of potential leads from Indian traditional medicinal plants against NAFLD. |
Organizations involved
Implementing Agency : | CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), Delhi Funding Agency :Council of Scientific and Industrial Research (CSIR), Government of India | Source (more info) :https://csirprojects.anusandhan.net/ | |