Research
Title : | Preclinical development of small molecules promoting hair regeneration and studying mechanism of hair regeneration |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Hair regeneration |
Principal Investigator : | Dr Mohd Jamal Dar, Scientist, CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | jamal@iiim.ac.in |
Details
Executive Summary : | Objective: Medicinal chemistry and in-vitro activity analysis of hits previously identified from IIIM Compound Repository as JAK-STAT and GSK-3-beta inhibitors for the lead development. Medicinal chemistry and in-vitro activity analysis of scaffolds based on pyrrolo¬pyrimidine and pyrazolo-pyrimidine scaffolds. Establishing and studying efficacy of identified leads using in vivo mouse models of hair regeneration for validation. Establishing and optimization of in vitro conditions for the proliferation and subsequent differentiation of hair follicle stem cells (HFSCs) and elucidating molecular mechanism regulating HFSC differentiation. |
Organizations involved
Implementing Agency : | CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu Funding Agency :Council of Scientific and Industrial Research (CSIR), Government of India | Source (more info) :https://csirprojects.anusandhan.net/ | |