Research
Title : | Study on the effect of a novel quorum sensing inhibitor isolated from Streptomyces sp. as an adjunct therapy molecule against latent and persisters in Mycobacterium tuberculosis |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Molecular medicine for Tuberculosis |
Principal Investigator : | Dr Vijay Chintaman Sonawane, Scientist, CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | yijay@imtech_res_in |
Details
Executive Summary : | Objective: Production, isolation and purification of the QSI molecule, unravelling its structure. iStudy on the effect of the QSI in lowering of MIC of antitubercular drugs by co-administration of QSI. Study on Inhibition of biofilm formation by M. tuberculosis/M. smegmatis in the presence of QSI (in vitro) . (RNS) tolerance in M. tuberculosis. Study on effect of QSI on DOS regulon in M. tuberculosis which is involved in latency. |
Organizations involved
Implementing Agency : | CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh Funding Agency :Council of Scientific and Industrial Research (CSIR), Government of India | Source (more info) :https://csirprojects.anusandhan.net/ | |