Patents

US10336703: Process for the synthesis of ivacaftor and related compounds

The patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

Filing Date: 10-11-2017

Issue Date: 02-07-2019

Applicant: CSIR-National Chemical Laboratory (CSIR-NCL), Pune

Patent No: US10336703

Application No: 15/573438

Inventor(s): Dumbala Srinivasa Reddy; Vasudevan Natarajan; Gorakhnath Rajaram Jachak

IPC Classification: C07D 215/56, A61K 31/47, C07B 33/00, C07C 227/06

Country: United States of America

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