US7189557: Process for the intracellular over-production of streptokinase using genetically engineered strain of e-coli

An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the overall process disclosed herein, concerns with an improvement in the fermentative production of streptokinase using an optimized growth medium mainly comprised of simple salts and trace-elements; thus, in principle, the process constitutes an improved and more economical means for the production of streptokinase which may be useful in thrombolytic therapy.