Patents

US8344150: Pyrrole end-capped bipyridine assay powder for selective detection of zinc ions and a process for the preparation thereof

The invention provides pyrrole end-capped bipyridine derivative having a general formula (1) useful for the detection of zinc ions in solution. The invention also provides a process for the preparation of pyrrole end-capped bipyridine derivative having a general formula (1). The invention further provides a dipstick device by coating the assay powder of formula (1) in alumina over a thermoplastic or a glass solid support. The detection event can be monitored by noting the color change and the intense fluorescence change on the surface of the dipstick. For zinc ions, in addition to the color change an intense fluorescence change from greenish-yellow to red is observed. Detection event by means of fluorescence change is selective for Zn2+ ions when compared with all other biologically important metal ions like Na+, K+, Ca2+; Mg2+, Cu2+. The dipstick is reusable, and can conduct the analysis of different samples using same stick.

Filing Date: 10-06-2028

Issue Date: 13-01-2001

Applicant: CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST),Thiruvananthapuram

Patent No: US8344150

Application No: 12/811008

Inventor(s): Ayyapanpilla Ajayaghosh; Sivaramapanicker Sreejith

IPC Classification: C07D 401/00

Country: United States of America

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