Research

Pharmaceutical Sciences

Title :

Bioprospecting the North-East Himalayan plants for its Cardioprotective activity through metabolomics approach

Area of research :

Pharmaceutical Sciences

Focus area :

Pharmaceutical Analysis, Metabolomics

Principal Investigator :

Prof. Radhakrishnanand Pullapanthula, National Institute of Pharmaceutical Education and Research (NIPER-G), Guwahati

Timeline Start Year :

2023

Details

Executive Summary :

Cardiovascular diseases (CVDs) are a major global health concern, causing lipid peroxidation, DNA damage, and protein oxidation. Angiotensin-II is linked to ROS production in cardiomyocytes, hypertrophy, and remodeling. Despite available pharmacological interventions, no undying treatment is available for myocardial infarction. This proposal explores therapeutic interventions against CVD, focusing on myocardial infarction. The study will use modern analytical tools to detect active components of medicinal plants, specifically Phlogacanthus thyrsiformis and Phlogacanthus curviflorus, traditionally used in the Assam region. The study aims to identify bioactive compounds, identify and characterize them, and evaluate their potential cardioprotective effects using an in vivo experimental cardioprotective model in rats.

Co-PI:

Dr. BidyaDhar Sahu, National Institute of Pharmaceutical Education and Research (NIPER-G), Guwahati

Total Budget (INR):

38,89,859

Organizations involved