Life Sciences & Biotechnology
Title : | Development of fluorescent carbon dots-based point-of-care biosensor for the detection of urinary neutrophil gelatinase-associated lipocalin. |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Nanotechnology and Biomedical Engineering |
Principal Investigator : | Mrs. Poornima, Chandigarh University, Mohali, Punjab (140413) |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | poornima23poonam@gmail.com |
Details
Executive Summary : | This research proposes the development of a point-of-care (POC) biosensor for non-invasive detection of uNGAL in CKD patients. The biosensor will be fabricated by immobilizing anti-NGAL antibodies over the surface of CDs, and a fluorometric LFIA will be developed for NGAL determination in spiked aqueous samples, artificial urine, and human urine samples. The fluorometric data will be transferred to a machine learning algorithm for quantitative digital output. The proposed research aims to provide a road map for future research on immunoassays for recognition of CKD-specific molecular biomarkers in a clinical environment, improving the quality of life for patients suffering from CKD. The project will yield an anti-NGAL/CDs-based immunosensor with a LFIA for detecting uNGAL, a machine learning approach for quantitative analysis of FL spectrophotometer data, and generate intellectual property in the form of a product. |
Total Budget (INR): | 19,01,880 |
Organizations involved