Executive Summary : | Pattern recognition receptors (PRRs) are proteins that play a crucial role in the innate immune system, recognizing specific molecular patterns found on pathogens. They trigger a series of signaling pathways that initiate the host's immune response to combat pathogens. There are several families of PRRs, with Toll-like receptors (TLRs) being the most characterized.
The project aims to develop novel vaccine adjuvants using ribose, a five-carbon sugar found in RNA. These adjuvants will be synthesized using triazole hybrid molecules of ribose and diverse amino acids with 2-aminobenzimidazole, ursolic acid, and 6-(chloromethyl)uracil to enhance their adjuvant activity. The project will investigate the use of ribose-modified RNA ligands as Toll-like receptor (TLR) agonists to enhance adjuvant activity and promote strong immune responses against infectious agents.
This project holds great potential for advancing vaccine adjuvant design and development, contributing to the fight against antibiotic-resistant infections and other global health challenges. Its significance lies in its potential to revolutionize vaccine development and improve global vaccination strategies. |