Executive Summary : | The liver is the major glandular organ with a critical function in metabolism. Liver produce and secretes bile, prothrombin, fibrinogen and heparin, which is a mucopolysaccharide sulfuric acid ester that helps keep blood from clotting within the circulatory system. Worldwide incidence of cirrhosis from autopsy studies ranges from 4.5% to 9.5% of the general population [1-3]. Hence, it is estimated that more than fifty million people in the world, taking the adult population, would be affected with chronic liver disease. It is reported that most common causative factors for chronic liver disease is alcohol, NASH and viral hepatitis. Frequency of cirrhosis is probable to be misjudged as approximately a third of the patients stay asymptomatic. With the use of non-invasive tests like transient elastography, a more realistic picture could emerge in the near future. During 2001, the estimated worldwide mortality from cirrhosis was 771,000 people, ranking 14th and 10th as the leading cause of death in the world and in developed countries, respectively[4]. Deaths from cirrhosis have been estimated to increase and would make it as the 12th leading cause of death in 2020[5]. Chronic liver cirrhosis treatment is one of the unmet goals for the medical professional till date. While in Herbalsystem of medicine is treating from many decade but step wise assessment of efficacy and validation of these drug are still not reported. There is urgent need to step wise development and validate of Herbalextracts for chronic liver cirrhosis. For thousands of years, nature has provided medicinal agents, and an impressive number of modern drugs have been isolated from natural sources, many of which are based on their use in traditional medicine. Many important pharmaceuticals now in use have been traced back to plants used by indigenous people (Balick et al., 1996). The use of any plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes is referred to as herbalmedicine or phytomedicine (Barrett et al., 1999). The medicinal plant's potential can be assessed by discovering new chemical entities with a wide structural diversity. Terminalia arjuna (Combretaceae) is a large tree that grows throughout South Asia. It is one of the most adaptable medicinal herbs. In this project proposal we proposed to develop aqueous plant extracts Terminalia arjuna (Combretaceae) with the help of Soxlet apparatus. Furthermore, extract going through all preformulation studies, physiochemical characterization, will be evaluated for hepatoprotective activity and transcriptomics analysis by invitro. |