Life Sciences & Biotechnology
Title : | Identification and functional characterization of novel Hv₁ channel inhibitors for neuroprotection |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Neurobiology, Pharmacology |
Principal Investigator : | Dr. Aravind singh kshatri, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | aravind.kshatri@cdri.res.in |
Details
Executive Summary : | Voltage-gated proton channels (Hv₁) are found in the microglia of mammalian nervous systems and are linked to neuroinflammation. Persistent activation of these channels contributes to chronic neuroinflammation and neurodegeneration. Currently, no Hv₁ inhibitors with reasonable affinity and selectivity exist. To address this, researchers aim to identify new classes of potent and selective Hv₁ channel inhibitors using a novel fluorescent-based HTS methodology. Hit compounds will be characterized using patch clamp electrophysiology, and structure-functional studies will generate lead compounds. The binding sites of identified Hv₁ inhibitors will be deduced using molecular docking, mutagenesis experiments, and mathematical modelling. Successful completion of this work could lead to the development of Hv₁ channel inhibitors as potential therapeutics for neurodegenerative diseases like Alzheimer's and Parkinson's. |
Total Budget (INR): | 27,64,800 |
Organizations involved