Executive Summary : | Cancer is a life threatening disease and day by day its seriousness is found to be increased. According to the World Health Organization, cancer ranks second in global causes of death, with an estimated 9.6 million deaths attributed to this group of diseases in 2018. India ranks third among nations in terms of highest number of cancer cases. Over 13 lakh people in India suffer from cancers every year, as per the National Cancer Registry Programme report. According to the recently published report of ICMR the number of Indians suffering from cancer is projected to increase to 29.8 million in 2025 from 26.7 million in 2021. Sedentary lifestyles, increase in urban pollution, trend to rise in obesity, tobacco and alcohol consumption, are said to be the reasons behind the rise. Currently, the most commonly employed cancer treatments include surgery, radiotherapy, and chemotherapy, while targeted therapies and immune therapies are receiving increasing attention. Chemotherapy remains the principal form of cancer treatment, and in recent years, much research has focused on the development of targeted therapies that bypass the off-target toxic side effects of chemotherapy. In the clinical situation, many cancer patients exhibit a poor response to conventional chemotherapy due to the development of resistance. With the poor efficacy and considerable toxicity of many current chemotherapeutics, there is a clear and urgent need for novel, effective, and nontoxic (NT) drugs for the treatment of cancer. Literature survey reveals that, chemotherapitic drugs presently practiced are having one or other kind of heterocyclic system in their molecular framework. It was also observed that more attention is paid on synthesis of Coumarines, Napthyridines and Indoles and evaluation of their anticancer properties. Some of the candidates of the series have displayed promising anticancer activities and their further investigation is in progress. Prompted by these observation of the problem under this proposal has been originated. Hence here initially virtual library of new heterocycles with basic heterocyclic rings like Coumarines, Napthyridines and Indoles each possessing other bioactive heterocycles as pharmacophoric moieties has been prepared and such individual molecules are computationally (In Silico) screened to evaluate their anticancer properties. Some of them have shown insilico activities and such possible anticancer agents are having 4-thiazolidinone, oxadiazole, benzodioxole, quinoline, piperazine and morpholine scaffolds in the basic separate molecular framework of Coumarines, Napthyridines and Indoles. Therefore to obtain potential safer anticancer agents the proposal entitled, “Novel Synthetic Routes and Anticancer Evaluation of Computationally Designed New Coumarines, Napthyridines and Indoles” will be undertaken and executed systematically and successfully. |