Life Sciences & Biotechnology
Title : | Aptamer based electrosensor for detection of NDMA impurity (a potential carcinogen) |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Oncology |
Principal Investigator : | Dr. Abhimanyu Dev, Birla Institute of Technology, Mesra, Ranchi, Jharkhand |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | abhimanyudev@bitmesra.ac.in |
Details
Executive Summary : | The proposal aims to develop a rapid and cost-effective method for detecting NDMA impurity in active pharmaceutical ingredients (APIs) and drug products. Nitrosamines are carcinogenic impurities found in many drug products, posing a serious threat to human health. The proposed method uses an aptamer-based electrosensor, which can detect NDMA impurity rapidly, eliminating the need for complex analytical methods. The electrosensor will be developed using capture sELEX technique, involving target-induced selection, enrichment, and isolation of DNA aptamers. The expected outcome is the development of an aptamer-based electrosensor for NDMA detection in APIs and pharmaceutical drug products. |
Co-PI: | Dr. Monika Dwivedi, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, Dr. Vimal Kumarsing Yadav, Birla Institute of Technology, Mesra, Ranchi, Jharkhand |
Total Budget (INR): | 39,86,300 |
Organizations involved