Life Sciences & Biotechnology
Title : | Artificial Light at Night (ALAN) and Gut Microbiota: A Study on the Rhythm Desynchronisation and its reversal through probiotics, in the zebrafish (Danio rerio) |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Prof. Asamanja Chattoraj, Kazi Nazrul University, West Bengal |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | asamanja.chattoraj@gmail.com |
Equipments : | Western Blot
Deep Freezer -20?C
Multi-Mode Microplate Reader |
Details
Executive Summary : | The research aims to investigate the impact of light on the body clock system, which is regulated by endogenous cellular oscillators. Light stimulates light-sensitive ganglion cells in peripheral organs, synchronizing behavioral processes and generating rhythm. Misalignment between natural light rhythm and modern life activities causes circadian rhythm disruption. Preliminary data suggests that alteration in feeding under continuous photic conditions may be a possible independent or interdependent pathway, affecting the homeostasis mechanism. The objectives include investigating the profile of gut microbiota under different photoperiodic exposure, identifying metabolic parameters of rhythm in circulation, exploring the possible gut microbiota signature, and examining the association of circadian parameters and gut microbiota signature in maintaining physiological homeostasis. The hypothesis is that a specific set of gut microbiota is essential for maintaining normal metabolic rhythm. The Alan can influence this pattern of gut microbiota and cause various metabolic arrhythmia. The identification of a specific composition of gut microbiota can be used to reverse the chronodisrupted metabolic behavior induced by ALAN. The Natural Light-Dark cycle is crucial for the origin and sustainability of the living world, and light is a zeitgeber for maintaining biological rhythm. Preliminary data demonstrated the influence of ALAN on rhythm desynchronization in peripheral organs, including the brain. Further research is needed to understand the rhythmicity of gut microbiota and the host circadian clock, and to develop probiotics for rhythm disruption. |
Total Budget (INR): | 51,92,240 |
Organizations involved