Research
Title : | Bioinformatic and structure-based approach towards developing low molecular weight proteins with nuclease and translational-Inhibitory activities as new potential anticancer agents |
Area of research : | Medical Sciences |
Focus area : | Stem Cell Research |
Principal Investigator : | Dr. Gowri Priya Chidambaranathan, Scientist, Aravind Medical Research Foundation (AMRF), Madurai, Tamilnadu |
Timeline Start Year : | 2015 |
Timeline End Year : | 2017 |
Contact info : | gowri@aravind.org |
Details
Executive Summary : | Regulation of nuclear transcription factor, ?Np63? by miR-203 has been reported in skin keratinocytes. In our investigation in non keratinized LESCs, we also report similar findings and have shown marked reduction in ?Np63? expression level after ectopic expression of miR-203. Moreover functionally the colony forming efficiency of miR-203 transfected cultured primary limbal epithelial cells were found to be reduced drastically. By repressing miR-203 with antagomicR treatment the colony forming efficiency has been rescued, and ?Np63? expression level was found to be high. |
Organizations involved
Implementing Agency : | Aravind Medical Research Foundation, Tamilnadu, 625020 Funding Agency :Indian Council of Medical Research (ICMR), New Delhi | |