Executive Summary : | This proposal is aimed at exploring the phosphine catalysis for the enantioselective gama-functionalization reactions. The phosphine catalysis has emerged in the past two decades as a powerful tool in organic synthesis. Recent years have witnessed explosive growth in the number of new phosphine-catalyzed reactions and their asymmetric variants. It provides reliable means to prepare synthetic intermediates and products in all areas of organic chemistry, including medicinal agents, natural products, ligands for catalysis, and materials. The phosphine-catalyzed reactions that are regularly mentioned are the Rauhut-Currier (RC) and Morita-Baylis-Hillman (MBH) reactions. since then, numerous groups have involved in this promising research field and enhanced the potential of phosphine catalysis, which made this domain one of the main pillars of organocatalysis today. Till now, most of the research has been focused on the use of phosphine catalyst for the enantioselective alpha-functionalization reactions. But there was no report involving the exploration of phosphine catalysis for enantioselective gama-functionalization reactions. The development of 1,6-addition reactions to an acceptor with extended conjugation is challenging task as the δ-position is less electropositive as compared to the beta-position due to the poor transmission of the charge density to the remote δ-position. This can be achieved either by increasing the steric crowding at the beta-position of the substrate or through designing a mode of activation that can make the δ-position more electropositive so that the catalyst adds to this position and make gama-position more nucleophilic. That's why, we have planned to achieve the goal of exploring phosphine catalysis for enantioselective gama-functionalization reactions. |