Executive Summary : | Study provided evidence of differentiating relapse and reinfection in P. vivax by newly designed minisatellite markers. These newly designed minisatellite markers are high polymorphic nature. This technique is simple, rapid, cost effective as compared to PCR-RFLP, sequencing, GeneMaper and heteroduplex systems. Minisatellite markers may also be applicable for allelic determination for field studies in areas having high vivax malaria. Genotyping of P. vivax by minisatellite marker has potential to link the infections in community-based studies on relapse, reinfection and transmission of disease also. The generated genotyping data in this study suggest that minisatellite markers are a potential tool to help, drug trial and evolutionary changes within P. vivax strains. |
Co-PI: | Dr. RC Dhiman, Scientist, National Institute of Malaria Research Delhi (NIMR), New Delhi, 110077
Dr. AR Anvikar, Scientist, National Institute of Malaria Research Delhi (NIMR), New Delhi, Dr. D Savargaonkar, Scientist, National Institute of Malaria Research Delhi (NIMR), New Delhi, Dr. N Mishra, Scientist, National Institute of Malaria Research Delhi (NIMR), New Delhi, 110077, Dr. N Valecha, Scientist, National Institute of Malaria Research Delhi (NIMR), New Delhi |