Executive Summary : | Biological samples contain biomarker levels that can determine human health, but traditional large-scale apparatuses are insufficient for on-site analysis. Developing portable sensors to detect biomarkers in biological samples is in high demand. Conscious organic field-effect transistors (OFETs) are a promising technology for developing such sensors due to their molecular recognition sites, high charge carrier mobility, on or off current ratio, low threshold voltage, solution processability, low-cost printing, superior flexibility, and compatibility with various substrates. However, OFET sensors often require high-voltage operation, which poses safety risks and low-power consumption demands in bio-electronics. Reducing operating voltage is a pre-requirement for biomolecule sensing in real-life wearable electronics. Reducing power consumption can be achieved by decreasing the applied gate voltage (VG), which can be achieved by increasing the capacitance of dielectrics. Ultra-thin and high-κ dielectrics are the best way to achieve the highest capacitance. To attain low-operational voltage, achieving steep-sub threshold voltage, reducing trap density, improving surface quality of dielectrics and electrodes, and suppressing current leakage are the best methods. This proposal aims to address the challenges in producing low-voltage operating flexible OFET sensors with good selectivity and sensitivity towards biomolecules. |