Research
Title : | Targeting Tumor microenvironment by rationally incorporating selenium into anti-inflammatory scaffolds: development of COX-independent chemo-protective and chemo-sensitizing agents |
Area of research : | Chemical Sciences |
Focus area : | Drug delivery |
Principal Investigator : | Dr. VenkataRao Kaki, National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, Telangana |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | kvenkatrao80@gmail.com |
Details
Executive Summary : | Nonsteroidal anti-inflammatory drugs (NsAIDs) have shown promise as anticancer agents, with their combination with chemotherapeutic drugs resulting in cancer prevention, chemosensitization, and reduced toxicities. However, prolonged use can lead to kidney failure and increased cardio-toxicity. Preclinical studies show that novel celecoxib-based analogues have significant efficacy and reduced toxicity in cancer cells. selenium and organoselenium molecules act as both anti-oxidants and pro-oxidants, depending on the cellular redox environment. synthesis of selenated derivatives of anti-inflammatory scaffolds could yield chemo-protective and chemo-sensitizing agents. Metabolically stable sel-heterocycles can be incorporated on NsAID scaffolds to leverage their therapeutic benefits. |
Total Budget (INR): | 49,25,966 |
Organizations involved
Implementing Agency : | National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, Telangana Funding Agency :Anusandhan National Research Foundation (ANRF) or science and Engineering Research Board (sERB) | Source :science and Engineering Research Board (sERB), DsT | |