Life Sciences & Biotechnology
Title : | Understanding the role of specific serotonin receptor signaling in modulating the antigen-specific immunity to control tumor growth |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. Girdhari Lal, National Centre For Cell Science, Maharashtra |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | glal@nccs.res.in |
Details
Executive Summary : | Chronic neuropsychological stress can modulate immunity and contribute to cancer development and progression. The neuro-immune crosstalk is increasingly being studied in various diseases, including cancer. Serotonin, a unique neurotransmitter, is synthesized in the gut by enterochromaffin cells and controls various peripheral functions, including immune cells. Serotonin signals through 15 receptor subtypes (5-HTR1-7) and a transporter (SERT) in various organs and cells. Increased 5-HTR-2B expression in colon cancer patients has a lower survival rate than those with low expression. The role of serotonin signaling in secondary lymphoid organs and tumor microenvironment in anti-tumor immunity is unclear. This study aims to investigate the extent of serotonergic system interaction in the tumor microenvironment and its effect on anti-tumor immunity, helping to understand this neuro-tumor-immune crosstalk and developing better therapeutic strategies to control tumor growth. |
Total Budget (INR): | 66,93,180 |
Organizations involved