Life Sciences & Biotechnology, Medical Sciences, Pharmaceutical Sciences
Title: | A Novel Molecule Effective for Non-steroidal Anti-inflammatory Drug Induced Gastropathy |
Area: | Life Sciences & Biotechnology, Medical Sciences, Pharmaceutical Sciences |
Focus Area: | Prevention of Gastric Mucosal Injury |
Patent: | EP2616439, JP5868980, US8901317 |
Social Benefits: | Discovered indigenously. Safe and stable. Immense therapeutic potential; These derivatives can chelate free iron, prevent oxidative stress by scavenging ROS and simultaneously offer anti-apoptotic effect in vitro. These derivatives have the ability to prevent the formation of iron-mediated. OH as well as scavenge ROS in vivo. We have shown that these derivatives can prevent gastric mucosal oxidative stress and gastropathy by preventing ROS-mediated activation of apoptosis in gastric mucosal cells induced by NSAIDs. This invention provides a new small molecule having gastroprotective efficacy and a new strategy for drug discovery in gastropathy |
Developing Agency: | CSIR-Indian Institute of Chemical Biology (IICB), West Bengal |
Technology Readiness Index: | Lab Validation |
Email: | director@iicb.res.in |
| Website Link : | http://www.iicb.res.in |
| Source (more info) : | https://t.ly/l_sb |
Brief Description
Description : | A novel small molecule which can prevent gastro trouble arising from use of pain killers. Tryptamine derivatives are useful as antioxidant and anti-apoptotic effect to prevent gastropathy/gastric mucosal injury induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), stress and ethanol. |
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