Research
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Title : | Grafting Halogen and Chalcogen Motifs in Peptidic Foldamers for Halogen and Chalcogen Bonding |
Area of research : | Chemical Sciences |
Focus area : | Supramolecular Chemistry and Structural Biology |
Principal Investigator : | Dr. Bishwajit Paul, Bangalore University, Karnataka |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | bishu[dot]nyu[at]gmail[dot]com |
Details
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Executive Summary : | The study aims to introduce halogen group and chalcogen motifs through tryptophan modifications in peptide sequences to study their interactions in folded peptides, including short macrocycles, short helices, and foldamers. The researchers will design, synthesize, and introduce these motifs in aromatic amino acids, followed by their incorporation in short and folded peptides and foldamers. They will also synthesize halogen group and chalcogen motifs containing L-Tryptophan for facilitating halogen bonding and chalcogen bonding in short peptides, using model peptide oligomers for macrocyclization. The study will also synthesize model short helices to probe the effect of halo-motifs bearing L-Tryptophan for halogen bonding and chalcogen bonding. This strategy could be used to include halo-motifs at the N-terminus, Mid-terminus, and C-terminus of the helix, providing a generic platform to explore the feasibility of halogen bonding and chalcogen bonding with termini dependence. |
Total Budget (INR): | 27,27,920 |
Organizations involved
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Implementing Agency : | Bangalore University |
Funding Agency : | Anusandhan National Research Foundation/ Science and Engineering Research Board |
Source : | Anusandhan National Research Foundation/Science and Engineering Research Board (SERB), DST 2023-24 |