Research
Title : | Design, Synthesis of Novel Naphthalene-Bipyridine appended Iridium (Nap-Ir) Photosensitiser for Targeted Nanoparticle Based Phototherapy in Breast Cancer Model |
Area of research : | Medical Sciences |
Focus area : | Photodynamic Therapy, Nanomedicine |
Principal Investigator : | Dr. K V Radhakrishnan, CSIR- National Institute For Interdisciplinary Science And Technology (Niist), Thiruvananthapuram, Kerala |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | radhupreethi@rediffmail.com |
Details
Executive Summary : | Combination treatment is a growing area of interest for researchers in other countries, as it can effectively destroy cancer by combining multiple therapeutic approaches. Multifunctional targeted drug delivery systems have been extensively investigated as potential cancer therapy options, with positive findings in pre-clinical animal tests. Antiglycolytic effect and synergistic phototherapy with highly targeted singlet oxygen delivery have shown potential to increase treatment efficacy and reduce adverse effects. The main objective of this proposal is to develop a targeted nano-delivery system made of natural melanin, loaded with a naphthalene-based Iridium complex endoperoxide for singlet oxygen delivery and co-loaded with an antiglycolytic agent to reduce ATP production and enhance therapeutic outcomes. |
Co-PI: | Dr. Kaustabh Kumar Maiti, CSIR- National Institute For Interdisciplinary Science And Technology (Niist), Thiruvananthapuram, Kerala-695019 |
Total Budget (INR): | 46,68,537 |
Organizations involved
Implementing Agency : | Csir- National Institute For Interdisciplinary Science And Technology (Niist), Kerala Funding Agency :Anusandhan National Research Foundation/ Science and Engineering Research Board | Source :Anusandhan National Research Foundation/Science and Engineering Research Board (SERB), DST 2023-24 | |