Life Sciences & Biotechnology
Title : | Fabrication of a novel mechanical thrombectomy device for the treatment of acute ischemic stroke due to large artery occlusion and in-vitro validation of its functional properties |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. Lingaraju Thyagaturu Shivakumaraswamy, National Institute Of Mental Health And Neurosciences, Banglore, Karnataka |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | drlingarajuts@gmail.com |
Equipments : | High accuracy analytical balance weighing scale
Hexa Core Workstation with 4GB graphic card and 16 GB RAM
Digital Pippete
Digital Camera with 1200x digital zoom
27 inch Desktop Monitor |
Details
Executive Summary : | The early generation mechanical thrombectomy devices has emerged as a time-tested emergency neuro-intervention for acute ischemic stroke. Despite the development in design aspects of the stent retriever devices since 20 years, the recanalization rates, currently, vary from 48% to 87%. Therefore, in order to improve the performance and reliability of such devices, we propose a novel stent retriever design that theoretically not only removes the blood clot in single attempt but also leaves no residual thrombus in situ. The presented design is presumed to trap the emboli within the device itself after filtering it from a finely porous self expanding resilient micro filamentous pouch present at its distal end. The device is expected to be fabricated from super-elastic metal alloys (i.e., nitinol shape memory alloy) coated with radiopaque marker that allows sufficient locomotion within the cerebral arteries as well as is resistant to collapse in vessel curves. Therefore, such a device can theoretically prevents distal embolisation and can provide a better success rate for the thrombus removal process compared to existing devices. The in-vitro evaluation and validation of the functional properties of the fabricated device prototype will be carried out using a comprehensive endovascular test bed of the intracranial that simulates the dynamic intravascular physiologic interaction between the embolus and the device in multiple cerebrovascular phantoms, embolus analogs and flow conditions. The project also aims to establish a state-of-the-art endovascular research lab housing a bench top experimental setup, an in-vivo simulator and an environment for conducting in-vitro experiments that not only allows us to test the performance of newly developed devices but also promote research in these unexplored domains in India. |
Total Budget (INR): | 22,53,724 |
Organizations involved