Research
Title : | Use of ultrasound contrast agents in detecting early stages of atherosclerosis |
Area of research : | Medical Sciences |
Focus area : | Medical Imaging and Cardiovascular Medicine |
Principal Investigator : | Prof. Dhiman Chatterjee, Indian Institute of Technology (IIT) Madras, Chennai, Tamilnadu (600036) |
Contact info : | dhiman@iitm.ac.in; syamsundariitm@gmail.com; mukeshd@iitm.ac.in; sulu_ajit57@yahoo.co.in; srramkumardr@yahoo.com |
Details
Executive Summary : | The research aims to develop cheaper diagnostic methods for atherosclerosis using ultrasound imaging. Ultrasound contrast agents (UCAs) are encapsulated microbubbles that scatter sound better than animal tissues. These microbubbles will be prepared in India and passed through tubes mimicking blood vessel stenosis configurations. The project aims to develop microbubble production technology and an imaging protocol for improved atherosclerosis imaging. Ultrasound contrast agents (UCAs) are used in contrast imaging, with two categories: first-generation commercial UCAs and second-generation commercial agents. The first generation uses nitrogen surrounded by a protein or hydrophilic particulate matter, while the second generation uses sparingly soluble gas like perfluorocarbon. These agents are more stable against gas diffusion and smaller in size, potentially used for myocardial perfusion or left ventricular imaging. However, FDA-approved UCAs are not available in India. The current research aims to develop cheaper diagnostic methodology using UCAs alongside ultrasound imaging techniques. The scope of the work includes developing microbubbles in the size range of 1-8 181m suitable for both coronary circulation and LV cavity opacification. The use of sparingly soluble gas and encapsulation material will ensure these microbubbles remain in circulation for a definite period without causing damage to body tissues. |
Co-PI: | Dr. C Syamsundar, CMR Engineering College, Hyderabad, Telangana (501401), Prof. Mukesh Doble, Indian Institute of Technology (IIT) Madras, Chennai, Tamil Nadu (600036), Dr. Mullasari Ajit Sankardas, The Madras Medical Mission, Institute of Cardio-Vascular Diseases, Chennai, Tamilnadu (600037), Dr. Soli Rajaram Ramkumar, The Madras Medical Mission, Chennai, Tamilnadu (600037) |
Total Budget (INR): | 13,50,240 |
Organizations involved
Implementing Agency : | Indian Institute of Technology (IIT) Madras, Chennai, Tamilnadu Funding Agency :Department of Science and Technology (DST) | Source :Department of Science and Technology (DST) | |