Research

Life Sciences & Biotechnology

Title :

mRNA based vaccine for SARS-CoV-2

Area of research :

COVID-19 Research, Life Sciences & Biotechnology

Focus area :

Vaccine for SARS-CoV-2

Principal Investigator :

Prof. Alok Srivastava, Christian Medical College (CMC), Vellore

Timeline Start Year :

2020

Contact info :

Details

Executive Summary :

This project aims to develop an mRNA based vaccine for SARS-CoV-2.

Outcome/Output:

Chemically modified spike mRNA was synthesised with lab designed 5’ and 3’ UTRs and validated functionally. The lyophilised mRNA-lipid nanoparticles were found to be stable at 4° C for up to a week that addresses a critical challenge in the transportation of mRNA vaccines. Promisingly vaccinated animals produced strong immune responses against spike protein and neutralised SARS-CoV-2 pseudovirus.

Organizations involved