Life Sciences & Biotechnology
Title : | Novel paradigms for the development of antioxidant-based radio-protective agent by targeting Nrf2 for ameliorating radiation-induced damages |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Molecular Biology |
Principal Investigator : | Dr. Tamizhselvan Gnanasekaran,
Assistant Professor,
K. S. Hegde Medical Academy, Mangalore |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | tamizh096@gmail.com |
Details
Executive Summary : | The study found that ferulic acid (FA) can reduce radiation-induced DNA damage in peripheral blood. FA was treated with Keap1-Nrf2 protein-protein interaction, a cellular drug target, and showed a significant reduction in reactive oxygen species and DNA damage. The study suggests that FA could be a potential radio-protective agent, with in silico approaches for screening as a better antioxidant-based radio-protector. Quantitative data is needed to understand biological processes in vitro/in vivo. |
Co-PI: | Dr. Gollapalli Pavan, NITTE University, Karnataka Dr. Suchetha Kumari N, NITTE University, Karnataka |
Total Budget (INR): | 28,59,400 |
Organizations involved