Life Sciences & Biotechnology
Title : | The role of interleukin (IL)-35 in dendritic cell suppression during Leishmania donovani infection |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Microbiology, cell biology, immunology |
Principal Investigator : | Dr. Pradip Sen,
Senior Principal Scientist,
CSIR – Institute Of Microbial Technology (IMTECH), Chandigarh |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | pradipsen68@yahoo.com |
Details
Executive Summary : | Visceral leishmaniasis, caused by Leishmania donovani, is the second most deadly parasitic disease globally. Its pathogenic factor is profound immunosuppression, which is largely unknown. Dendritic cells (DCs) play a crucial role in initiating antileishmanial immune responses. The study aims to investigate if LD induces IL-35 expression in DCs, how LD mediates this effect, and if DC-derived IL-35 has any role in suppressing DCs, T cells, and antileishmanial immunity. This research will help understand the innate immune mechanism by which LD induces immunosuppression to promote the disease. |
Co-PI: | Dr. S Kumaran, CSIR – Institute Of Microbial Technology (IMTECH), Chandigarh |
Total Budget (INR): | 61,24,280 |
Organizations involved