Life Sciences & Biotechnology
Title : | Synthesis and evaluation of novel dual GSK-3β/HDAC inhibitor as an anti-Alzheimer agent |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Pharmaceuticals, Neurology |
Principal Investigator : | Dr. Abha Sharma, Associate Professor,
National Institute of Pharmaceutical Education and Research, Raebareli |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | abha.sharma@niperraebareli.edu.in |
Details
Executive Summary : | A dual classical GSK-3β/epigenetic HDAC6 inhibitor is designed using a multi-target strategy for modulating Alzheimer's disease (AD) targets. The pyrimidone-based series of derivatives will be synthesized using four multistep schemes. The proposed molecules will undergo enzymatic assays, toxicity studies, acute toxicity, memory and cognitive improvement evaluation, and biochemical evaluation. Only one international research study is available. |
Total Budget (INR): | 37,31,040 |
Organizations involved
