Life Sciences & Biotechnology
Title : | Development of b-hairpin peptidomimetics and self-assembled ultrashort hybrid peptide nanostructures as anti-infective agents |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Molecular pathway of ultrashort peptide nanostructures |
Principal Investigator : | Dr Rajkishor Rai, Scientist, CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | raj@iiim.ac.in |
Details
Executive Summary : | Objective: Design and synthesis of peptides incorporating non-coded amino acids derived from naturally occurring cationic antimicrobial protegrins; Design and synthesis of self-assembled ultrashort hybrid peptides containing [¬and y-amino acids; Structural characterization of peptides using Mass, NMR (1 D & 20), scanning electron microscope (SEM), transmission electron microscopy (TEM), circular dichroism (CD) and X-ray crystallographic techniques; Identification new potent peptides by screening the designed protegrins derived peptides against Gram-negative bacterial strains; Investigation of structure-activity relationships of B-hairpin peptidomimetics; Evaluation of most potent peptides against antimicrobial resistance strains (AMRs). |
Organizations involved