Research
Title : | Development of macro-encapsulation device for islet cell transplantation for diabetes treatment |
Area of research : | Material Sciences, Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Materials for better health/health services |
Principal Investigator : | Subha Narayan Rath, Associate Professor, Dept. of Biomedical Engineering, Indian Institute of Technology (IIT), Hyderabad |
Details
Executive Summary : | We plan to indigenously develop a macroencapsulation device for cellular therapy, especially islet transplantation in the management of uncontrolled diabetes. The basic aim is to use allogenic or xenogeneic cells in a macroencapsulation device in which, the cells secrete the required proteins without being affected by host immune cells attacking them. The porous chamber should allow the smaller protein molecules to pass out and nutrients like glucose, amino acids to pass in; but should not let the bigger immune cells to enter into the device. |
Co-PI: | Chandra Sekhar Sharma, Associate Professor, Indian Institute of Technology Hyderabad, Dr GV Rao, Asian Institute of Gastroenterology, Hyderabad, Dr R Pradeep, Asian Institute of Gastroenterology (AIG), Hyderabad, Dr M Sasikala, Head (Research), Asian Institute of Gastroenterology (AIG), Hyderabad, Dr R Talukdar, Asian Institute of Gastroenterology (AIG), Hyderabad, Dr D Nageshwar Reddy, Asian Institute of Gastroenterology (AIG), Hyderabad |
Total Budget (INR): | 1,27,01,000 |
Organizations involved
Implementing Agency : | Indian Institute of Technology (IIT), Hyderabad Asian Institute of Gastroenterology, Hyderabad Funding Agency :Indian Council of Medical Research (ICMR), New Delhi | |