Research
Title : | Discovery of structure-based antivirals against SARS-CoV-2 targeting key viral genome replication enzymes |
Area of research : | COVID-19 Research, Life Sciences & Biotechnology |
Focus area : | COVID-19 Therapeutics |
Principal Investigator : | Prof Pravindra Kumar, Indian Institute of Technology (IIT) Roorkee |
Timeline Start Year : | 2020 |
Contact info : | pravshai@gmail.com |
Details
Executive Summary : | The project proposes to use structure-based screening of antivirals against SARS- CoV-2 targeting key viral genome replication enzymes such as viral protease that are responsible for the cleavage of non-structural polyprotein and their activation; RNA dependent RNA polymerse as it carries out both primer-independent and primer-dependent synthesis of viral RNA; and G-N7-MTase (nsp14) responsible for camouflaging and obscuring viral RNA from host cell sensing machinery. |
Organizations involved
Implementing Agency : | Indian Institute of Technology (IIT) Roorkee Funding Agency :Department of Science and Technology (DST), Govt of India | |