Life Sciences & Biotechnology
Title : | Exploration of diet (plant) derived exosomal miRNAs for inhibiting key metastatic targets in breast cancer cells |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Breast Cancer |
Principal Investigator : | Dr Priya S, Senior Scientist, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Kerala |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | priyasulu@niist.res.in |
Details
Executive Summary : | Objective: Isolation of exosomes from Ginger, Garlic, Turmeric and Amla which are known to have anticancer properties. • Biophysical characterization of exosomes (using DLS, SEM and AFM). • Fluorescent tagging of exosomes and studying its cellular uptake status (in normal and cancer cells). • Effects of isolated exosomes in the regulation of metastatic genes/proteins in breast cancer cells. • Isolation and characterization of miRNAs from the isolated plant exosomes. • Transfection of specific plant exosomal miRNAs to target cells and studying their effects on the expression of metastatic genes and proteins. |
Organizations involved