Life Sciences & Biotechnology
Title : | Health care supply chain and capacity modelling during a pandemic |
Area of research : | COVID-19 Research, Life Sciences & Biotechnology |
Focus area : | COVID-19 Management |
Principal Investigator : | Dr P Chellapandi, Professor, Bharathidasan University, Tamil Nadu |
Timeline Start Year : | 2020 |
Contact info : | pchellapandi@gmail.com |
Details
Executive Summary : | The study attempts to investigate clinically, FDA-approved drugs or drug combinations for COVID-19 by computing network proximity approximations in drug-SARS-CoV-2–host interactions. |
Outcome/Output: | Constructed a systems medicine framework for repurposing drugs for COVID-19 in people with type 2 diabetes and hypertension. Cellular antiviral targets from virus-host protein interactions have been identified for each drug and then evaluated them with gene functional enrichment analysis. A total of 174 repurposable drugs were identified by quantifying the interplay between virus-host protein interactions and drug targets in the human protein network. As a result, there are no involvements in host gene expression, biological processes, and side effects for fostamatinib. It suggests that fostamatinib is a repurposed drug for the treatment of systemic COVID-19 patients with clinical comorbidities (T2DM and HT). |
Organizations involved