Life Sciences & Biotechnology
Title : | Mechanism of action of spermidine in pathogenesis of Salmonella, Shigella and Staphylococcus |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Biogenesis in pathogen |
Principal Investigator : | Dr Dipak Dutta, Scientist, CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | dutta@imtech.res.in |
Details
Executive Summary : | Objective: Unravelling how spermidine over-accumulation in the Salmonella AspeG strain blocks intracellular replication; Showing the link between spermidine over-accumulation and superoxide production in the pathogens; Demonstrating how spermidine over-accumulation affects iron-sulfur cluster biogenesis in pathogen; Assessing the advantages or disadvantages of superoxide production and skewed iron homeostasis under spermidine stress in the pathogenesis of Shigella and Staphylococcus. |
Organizations involved