Life Sciences & Biotechnology
Title : | Mechanism of chiral proofreading of DTD2 from archaea and plants |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Biochemistry, Structural Biology |
Principal Investigator : | Dr. Rajan Sankaranarayanan, CSIR- Centre For Cellular And Molecular Biology (CSIR–CCMB), Hyderabad, Telangana |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | sankar@ccmb.res.in |
Details
Executive Summary : | Land plants have developed metabolic pathways that involve the production of reactive aldehydes and their detoxification to survive harsh environments. A chiral proofreader, DTD2, plays a critical role in detoxifying anaerobic stress-induced acetaldehyde modification of D-aminoacyl-tRNA. This study aims to identify DTD2's role in protecting plants from metabolically generated aldehydes, elucidating its mechanism of chiral selectivity and adduct activity, and identifying key residues involved in its biochemical activities. Understanding molecular determinants providing aldehyde modification specificity in DTD2 can help engineer DTD2 protein for a broader range of protection from various cellular metabolites. |
Total Budget (INR): | 68,21,020 |
Organizations involved