Life Sciences & Biotechnology
Title : | Quality control of regulatory complex biogenesis |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Biogenesis |
Principal Investigator : | Dr Sawasti Raychaudhuri, Scientist, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | director@ccmb.res.in |
Details
Executive Summary : | Objective: Development of alpha-Synculein aggregation model in cell culture; Mutation in mitochondrial genes and development of Oxphos-deficiency models; Validation of candidate assembly chaperones by RC-activity assays; Characterisation of candidate assembly chaperones; Deregulation of RC biogenesis in Oxphos-deficiency models; Testing efficiency of newly identified assembly chaperones in improving cellular respiration in 18-36 months. |
Organizations involved