Research

Life Sciences & Biotechnology

Title :

A rapid approach to generate immortalised B cells for monoclonal antibody generation from SARS-CoV-2 recovered and vaccinated group

Area of research :

COVID-19 Research, Life Sciences & Biotechnology

Focus area :

Monoclonal antibody generation

Principal Investigator :

Dr TR Santhosh Kumar, Scientist, Rajiv Gandhi Centre for Biotechnology (RGCB), Kerala

Timeline Start Year :

2020

Contact info :

Details

Executive Summary :

This study aims to identify subset of COVID-19 recovered patients and immunised volunteers with high titer neutralising antibodies for the in vitro B cell immortalisation for neutralising antibody generation.

Outcome/Output:

The antibody response heterogeneity reported in COVID-19 infected patient and immunised population is huge. The potential utility of such repertoire of antibodies with viral neutralising activity is yet to be fully exploited for diagnostic or therapeutic purpose. This requires a high efficient approach to identify high neutralising antibody response and selection and expansion of respective B cells producing antibodies.

Organizations involved