Life Sciences & Biotechnology
Title : | Regulation of fatty acid desaturases and transport proteins in pregnancy |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Nutrition |
Principal Investigator : | Asmita Joshi, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Medical College Campus, Maharashtra |
Timeline Start Year : | 2013 |
Timeline End Year : | 2014 |
Contact info : | srjoshi62@gmail.com;
kaleanvita@gmail.com |
Details
Executive Summary : | The present study for the first time indicates several novel findings in mothers delivering low birth weight babies 1). Reduced folate levels and increased homocysteine levels 2). Reduced maternal and placental omega 3 fatty acid (ALA and DHA) levels, 3). increased FABP3 protein levels. This study also reports a positive association between positive association between maternal vitamin B levels and placental mRNA as we as protein levels of desaturases while maternal plasma homocysteine levels were inverse association with desaturases and transport proteins in the placenta. Further the positive association of maternal micronutrients with maternal and placental fatty acids and negative association of homocysteine with placental mRNA levels of A5 desaturase, transport protein (FATP and FATP4) and binding protein (FABPI and FABP3) suggests that disturbed one carbon metabolism affects fatty acid metabolism in placenta. |
Co-PI: | Dr. Sadhana Joshi, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Medical College Campus, Maharashtra, Dr. Anvita Kale, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Medical College Campus, Maharashtra, Dr. Savita Mehendale, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Medical College Campus, Maharashtra |
Achievements : | One project trainees |
Publications : | 1 |
Outcome/Output: | Our findings are of significance since the placental transfer of LCPUFA during pregnancy is reported to play a key role in the neurological development of the foetus. Thus children born with LBW may be at a future risk for neurodevelopmental disorders. |
Organizations involved