Life Sciences & Biotechnology
Title : | Structural and functional characterization of potential drug target proteins from ESKAPE pathogens |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Characterization of potential drug target |
Principal Investigator : | Dr Ashish Arora, Scientist, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | director@cdri.res.in |
Details
Executive Summary : | Objective: Cloning, expression, and purification of selected targets. Characterization of their folding, solubility and stability . Isotopic labeling and determination of NMR solution structure of selected targets. Crystallization and determination of crystal structure of selected targets. Harnessing of structural information for the design of inhibitors. Testing of new and known inhibitors for enzyme inhibition and antimicrobial activity. |
Organizations involved