Research
Title : | Targeting Artemisinin-Resistant Malaria through Innovative Plasmodium falciparum GCN5 HAT Inhibitors |
Area of research : | Medical Sciences |
Focus area : | Antimalarial Drug Development, Epigenetics |
Principal Investigator : | Dr. Neha Sharma, Indian Institute of Science Education and Research (IISER) Pune, Maharashtra |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | nehasharma0024@gmail.com |
Details
Executive Summary : | Plasmodium falciparum, which causes malaria, is still a serious threat to world health, and drug resistance makes it difficult to treat it effectively. In P. falciparum, histone acetyltransferase GCN5 (HAT: GCN5) has recently come to light as a crucial factor in the regulation of genes linked to artemisinin resistance and stress response. This study proposal sought to develop novel PfGCN5 inhibitors that would interfere with the gene regulatory functions of this protein and improve the effectiveness of malaria treatment. |
Organizations involved
Implementing Agency : | Indian Institute of Science Education and Research (IISER) Pune, Maharashtra Funding Agency :Anusandhan National Rsearch Foundation (ANRF)/Science and Engineering Research Board (SERB) | Source :Anusandhan National Research Foundation/Science and Engineering Research Board (SERB), DST 2023-24 | |